Two drugs that are commonly used off-label in the treatment of male infertility are clomiphene citrate (CC) and anastrozole (AZ);

however, data are lacking on the use of combination CC+AZ therapy. A new BJU International study found that combination CC+AZ therapy is safe and effective for patients with elevated estradiol or a low testosterone/estradiol ratio.

Source: Wiley

Full bibliographic information

Nathan J. Alder, Sorena Keihani, Gregory J. Stoddard, Jeremy B. Myers and James M. Hotaling. Combination therapy with clomiphene citrate and anastrozole is a safe and effective alternative for hypoandrogenic subfertile men. BJU International. DOI: 10.1111/bju.14390.